Integrative Biology — Membrane Transport, Cell Structure, and Energetics: Comprehensive Exam Notes Practice Quiz

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Which of the following molecules is most likely to cross the phospholipid bilayer by simple diffusion (without a transport protein)?

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Correct answer:

O_2

Simple diffusion favors small, uncharged, nonpolar molecules. Gases like $O_2$ diffuse directly through the hydrophobic core of the bilayer, whereas charged species like $Na^+$ and $Cl^-$ and polar amino-acid–derived molecules like glutamate require transport proteins.

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